Clyne, Alisa Morss
Professor
Associate Chair, Diversity, Equity, and Inclusion
Fischell Fellow
ADVANCE Professor
Associate Chair, Diversity, Equity, and Inclusion
Fischell Fellow
ADVANCE Professor
Fischell Department of Bioengineering
Brain and Behavior Institute
Robert E. Fischell Institute for Biomedical Devices
Brain and Behavior Institute
Robert E. Fischell Institute for Biomedical Devices
4224 A. James Clark Hall
Ph.D., Medical and Mechanical Engineering, Massachusetts Institute of Technology
M.S., Mechanical Engineering, University of Cincinnati
B.S., Mechanical Engineering, Stanford University
B.S., Mechanical Engineering, Stanford University
Dr. Clyne is director of the Vascular Kinetics Laboratory, which unravels the complexity of vascular diseases ranging from the very common (atherosclerosis, Alzheimer's disease) to the very rare (Niemann Pick). She is particularly interested in how altered blood flow (e.g., during exercise or at an arterial bifurcation) and altered blood metabolites (e.g., high glucose in diabetes) contribute to disease in people from diverse backgrounds. The laboratory uses 3D in vitro systems, computational models, and animal and human studies to discover fundamental biological mechanisms, which then enable innovative vascular disease therapies.
Dr. Clyne is a fellow of the American Society of Mechanical Engineering (ASME), Biomedical Engineering Society (BMES), American Heart Association (AHA), and the American Institute for Medical and Biological Engineering (AIMBE). She received the NSF CAREER award in 2008, an AHA National Scientist Development Grant in 2010, and the BMES-CMBE Rising Star award in 2011. Her research and educational innovations are funded by NSF, NIH, AHA, and the Department of Education. She is proud of receiving the Elizabeth Bingham mentoring award from the Association for Women in Science in recognition of her life-long efforts to promote diversity in science and engineering.
Dr. Clyne's Vascular Kinetics Laboratory conducts research at the interface of engineering, biochemistry, and vascular biology. In their prior work, the group largely focused on how an altered glucose environment (e.g., in diabetes) impaired endothelial cell response to shear stress and cyclic strain. Dr. Clyne and her lab have demonstrated that endothelial cells in high glucose do not respond appropriately to mechanical stimuli. Today, the group focuses primarily on the opposite question: how the mechanical environment affects endothelial cell glucose metabolism. They are integrating mechanobiology and metabolism, with the hope of using metabolic engineering to decrease the burden of cardiovascular disease and cancer. With new collaboration opportunities at the University of Maryland, Dr. Clyne and her lab group plan to extend their cell and animal work into human studies.
- Laminar and disturbed flow effects on endothelial glucose metabolism
- Computational models of endothelial glucose metabolism
- Impaired endothelial mechanosensing in pulmonary arterial hypertension
- Arterial stiffness in spinal cord injury
- Perfusion effects on cancer metabolism
- Vascular glucose transport in traumatic brain injury and Alzheimer’s disease
- Pressure myography-on-a-chip
- Energy Fields to Control Mitochondrial Metabolism
Agents of Positive Change: Highlighting Women Maryland Engineers
In celebration of Women's History Month, we highlight some of the important contributions of women engineers within our campus community.24 Teams Present at BIOE Capstone Competition Including First BCE Students
On May 8, 2023, 24 teams presented novel designs at the BIOE Capstone Design Competition.Five BIOE Students & Alumni Named NSF Graduate Research Fellows
The NSF Graduate Research Fellowship Program (GRFP) was established to ensure the vitality and diversity of the scientific and engineering workforce of the United States.Recent Bioengineering Graduate Awarded National Mitchell Scholarship
Neelesh Mupparapu (B.S. bioengineering '22) named one of 12 winners to pursue graduate study in IrelandDo Suddenly Self-Centered Brain Cells Promote Disease?
NSF Award Funds UMD Alzheimer’s Research Into Brain Glucose Metabolism$7.9 Million in NIH Awards Propel UMD Aging Research
New multidisciplinary collaborations take on challenges like Alzheimer’s disease prevention.Celebrating 14 Participants of 2021 BIOE REU Program
The BIOE REU program promotes collaboration between UMD and the FDA, making it unlike any other in the countryMaisel to Investigate Little-Known Organ in the Body
Dr. Katharina Maisel was awarded a $1.8 million NIH NIGMS grant to study the interstitium and lymphatics.Maryland Graduate Engineering Ranked #10 Public in the Nation
From extreme batteries to windows made from wood, Clark School’s trendsetting work ranks it among the country’s Top 10 public engineering schools for the 3rd consecutive year.One Size Does Not Fit All
To advance inclusive medical therapies and diversity in fundamental science, one Maryland engineer leads by example.BBI Awards Seed Grants to Six Interdisciplinary Projects
Funded teams feature UMD faculty from 15 academic departments and six centers and institutesClyne Named BIOE Associate Chair, Diversity, Equity & Inclusion
Role will support efforts to enhance diversity within the department and in the STEM fields at large.BIOE Capstone Class Virtually Presents 24 Novel Projects
BIOE seniors present Capstone projects and celebrate winners virtually.Clyne, Jewell Inducted into AIMBE College of Fellows
BIOE faculty awarded one of the highest professional distinctions accorded to a medical/biological engineer.Clyne, Maisel to Join BIOE Faculty in 2019
Associate, assistant professors bring expertise in endothelial cell biology, mucosal drug delivery.American Society of Mechanical Engineers (ASME)
- American Heart Association
- American Institute for Medical and Biological Engineering
- American Society of Mechanical Engineers