Faculty Directory

Ma, Lan

Ma, Lan

Biocomputational Engineering Program Director and Faculty Instructor
Biocomputational Engineering
Fischell Department of Bioengineering
4121 Biomedical Sciences and Engineering, Universities at Shady Grove

B.E. Huazhong University of Science & Technology, China Control Engineering
M.S.E. Johns Hopkins University Electrical & Computer Engineering
Ph.D. Johns Hopkins University Electrical & Computer Engineering

 

Ph.D.

  • Thesis title: “Feedback control in the chemotactic pathway of Dictyostelium discoideum”
  • Thesis advisor: Prof. Pablo A. Iglesias

University of Maryland, College Park

  • 2016, Spring, BIOE420, Bioimaging 
  • 2016, Fall, BIOE404, Biomechanics 
  • 2017, Spring, BIOE241, Biocomputational Methods 
  • 2017, Spring, BIOE404, Biomechanics 
  • 2017, Spring, BIOE486, Capstone Design II
  • 2017, Fall, BIOE371, Linear Systems & Ordinary Differential Equations for Bioengineering Applications 
  • 2018, Spring, BIOE241, Biocomputational Methods 
  • 2018, Spring, BIOE371, Linear Systems & Ordinary Differential Equations for Bioengineering Applications 
  • 2018, Summer, BIOE241, Biocomputational Methods 
  • 2018, Fall, BIOE371, Linear Systems & Ordinary Differential Equations for Bioengineering Applications 

 

Journal Publications:

  • R. Ziraldo and L. Ma. “Computing intrinsic noise of the genetic regulation modeled by Hill functions.” Journal of Computational Systems Biology, 2 (1): 102, 2018.
  • T. Quarton, K. Ehrhardt, J. Lee, S. Kannan, Y. Li, L. Ma and L. Bleris. “Mapping the operational landscape of microRNAs in synthetic gene circuits.” npj Systems Biology and Applications, 4 (6). doi:10.1038/s41540-017-0043-y, 2018.
  • R. Moore, H. Ooi, T. Kang, L. Bleris and L. Ma. “'MiR-192-mediated positive feedback loop controls the robustness of stress-induced p53 oscillations in breast cancer cells.” PLoS Computational Biology, 11(12):e1004653. doi:10.1371/journal.pcbi. 1004653, 2015.
  • R. Ziraldo and L. Ma. “A mathematical model for apoptotic switch in Drosophila.” Physical Biology, 12 (056003). doi:10.1088/1478-3975/12/5/056003, 2015.
  • R. Ziraldo, N. Link, J. Abrams and L. Ma. “Toward automatic image analysis and assessment of multicellular apoptosis process.” IET Image Processing. doi: 10.1049/iet- ipr.2014.0531, 2014.
  • L. Ma and R. Ranganathan. “Systems-level characterization of the kernel mechanism of the cyanobacterial circadian oscillator.” Elsevier BioSystems, 117: 30-39, 2014.
  • H. Ooi and L. Ma. "Modeling heterogeneous responsiveness of intrinsic apoptosis pathway”. BMC Systems Biology, 7:65, 2013.
  • L. Ma and R. Ranganathan. “Quantifying the rhythm of KaiB-C interaction for in vitro cyanobacterial circadian clock.” PLoS ONE 7(8): e42581. doi:10.1371/journal.pone.00 42581, 2012.
  • W. Hu, Z. Feng, L. Ma, J. Wagner, J. J. Rice, G. Stolovitzky and A. J. Levine. “A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.” Cancer Research, 67(6): 2757-65, 2007.
  • J. Kim, D. G. Bates, I. Postlethwaite, L. Ma and P.A. Iglesias. “Robustness analysis of a molecular network model for oscillations in excitable cells of Dictyostelium”. IEE Systems Biology, 153(3): 96-104, 2006.
  • J. Wagner, L. Ma, J. J. Rice, W. Hu, A. J. Levine and G. Stolovitzky. “The p53-Mdm2 loop is controlled by a balance of its feedback strength and effective dampening via ATM and delayed feedback.” IEE Systems Biology, 152(3): 109-118, 2005.
  • L. Ma, J. Wagner, J. J. Rice, W. Hu, A. J. Levine and G. Stolovitzky. “A plausible model for the digital response of p53 to DNA damage.” Proc Natl Acad Sci USA 102 (40): 14266-14271, 2005.
  • L. Ma, C. Janetopoulos, L. Yang, P. N. Devreotes and P. A. Iglesias. “Two local excitation, global inhibition mechanisms acting complementarily in parallel can explain the chemoattractant-induced PI(3,4,5)P3 response in Dictyostelium.” Biophysical Journal, 87(6): 3764-74, 2004.
  • C. Janetopoulos, L. Ma, P. N. Devreotes and P. A. Iglesias. “Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton.” Proc Natl Acad Sci USA 101 (24): 8951-6,  2004.
  • S. Paliwal, L. Ma, J. Krishnan, A. Levchenko, P. A. Iglesias. “Responding to Directional Cues: A Tale of Two Cells.” IEEE Control Systems Magazine 24 (4): 77- 90, 2004.
  • L. Ma and P. A. Iglesias. “Quantifying robustness of biochemical network models”. BMC Bioinformatics, 3:38, 2002.
  • L. Ma and Y. Zhang. “Multiobjective genetic algorithm and its application to the design of automatic control system.” (in Chinese) Journal of Systems Engineering and Electronics: pp. 71 – 76, 1997.

 


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